Research table: Lumpectomy plus radiation therapy for DCIS
This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. However, to get the most out of the tables, it’s important to understand some key concepts. Learn how to read a research table.
Introduction: Ductal carcinoma in situ (DCIS) is a non-invasive breast cancer.
Without treatment, DCIS can progress to invasive breast cancer over time. So, almost all cases of DCIS are treated.
Treatment involves surgery, with or without radiation therapy. Some people may also get hormone therapy (tamoxifen or an aromatase inhibitor).
Lumpectomy for DCIS is usually followed by radiation therapy to lower the risk of :
- DCIS recurrence (a return of DCIS) in the treated breast
- Invasive breast cancer in the treated breast
Overall survival appears similar for women with DCIS who have lumpectomy with or without radiation therapy [2-3].
Radiation therapy isn’t given to people who are treated with mastectomy for DCIS.
Learn more about treatment for DCIS.
Learn about the strengths and weaknesses of different types of studies.
Study selection criteria: Randomized clinical trials with at least 500 participants and 5 or more years of follow-up, and meta-analyses.
Percent of Women who Developed
No Radiation Therapy
Randomized clinical trials
UK, Australia, New Zealand (UK/ANZ) DCIS Trial 
Swedish Breast Cancer Group 
European Organization for Research and Treatment of Cancer (EORTC) 
National Surgical Adjuvant Breast and Bowel Project (NSABP) B-17 
Radiation Therapy Oncology Group 
Less than 1%
Cochrane Collaboration 
Stuart et al. 
* Invasive breast cancer in the breast treated for DCIS
† Breast cancer survival (not overall survival)
- National Comprehensive Cancer Network (NCCN). NCCN Clinical practice guidelines in oncology: Breast cancer V.1.2022. https://www.nccn.org/, 2021.
- Goodwin A, Parker S, Ghersi D, Wilcken N. Post-operative radiotherapy for ductal carcinoma in situ of the breast. Cochrane Database Syst Rev. (4):CD000563, 2009.
- Correa C, McGale P, Taylor C, et al. for the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr. 2010(41):162-77, 2010.
- Cuzick J, Sestak I, Pinder SE, et al. Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. Lancet Oncol. 12(1):21-9, 2011.
- Wärnberg F, Garmo H, Emdin S, et al. Effect of radiotherapy after breast-conserving surgery for ductal carcinoma in situ: 20 years follow-up in the randomized SweDCIS Trial. J Clin Oncol. 32:3613-18, 2014.
- Donker M, Litière S, Werutsky G, et al. Breast-conserving treatment with or without radiotherapy in ductal carcinoma in situ: 15-year recurrence rates and outcome after a recurrence, from the EORTC 10853 randomized phase III trial. J Clin Oncol. 31(32):4054-9, 2013.
- Wapnir IL, Dignam JJ, Fisher B, et al. Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS. J Natl Cancer Inst. 103(6):478-88, 2011.
- McCormick B, Winter K, Hudis C, et al. RTOG 9804: A prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation. J Clin Oncol. 33(7):709-15, 2015.
- Goodwin A, Parker S, Ghersi D, Wilcken N. Post-operative radiotherapy for ductal carcinoma in situ of the breast. Cochrane Database Syst Rev. 11:CD000563, 2013.
- Stuart KE, Houssami N, Taylor R, Hayen A, Boyages J. Long-term outcomes of ductal carcinoma in situ of the breast: a systematic review, meta-analysis and meta-regression analysis. BMC Cancer. 15:890, 2015.